Journal
FITOTERAPIA
Volume 109, Issue -, Pages 8-13Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.11.019
Keywords
Spiraea japonica; Atisine-type diterpene alkaloids; Atisane-type diterpenes; Anti-TMV activities
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Funding
- Scientific and Technological Planning Project of Guizhou [QKH-NZ (2011) 3002]
- Modernization of Traditional Chinese Medicine [QKH-NZ (2011) 5085]
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Five new naturally occurring natural products, including two atisine-type diterpene alkaloids (1 and 2), two atisane-type diterpenes (3 and 4), and,a new natural product spiramine C2 (5), along with nine known ones (6-14), were isolated from the ethanolic extracts of the whole plant of Spiraea japonica var. acuminata Franch. Their structures were elucidated by extensive spectroscopic analysis. The anti-tobacco mosaic virus (TMV) activities of all the compounds were evaluated by the conventional half-leaf method. Six compounds (2, 3, 6, 7, 11, and 12) exhibited moderate activities at 100 gg/mL with inhibition rates in the range of 69.4-92.9%, which were higher than that of the positive control, ningnanmycin. Their preliminary structure-activity relationships were also discussed. (C) 2015 Elsevier B.V. All rights reserved.
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