Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 97, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2021.107819
Keywords
NLRP3 inflammasome; Tanshinone; Dihydrotanshinone I; Mitochondrial reactive-oxygen species; Septic shock; Gout
Categories
Funding
- National Natural Science Foundation [81872743]
- Guangzhou Medical University [G2016013]
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Tanshinones, derived from the roots of Salvia miltiorrhiza, are active ingredients widely used in traditional medicine for treating inflammatory diseases. This study identified 15 tanshinones that suppress the activation of NLRP3 inflammasome, with specific tanshinones showing potential mitochondrial protection via promoting autophagy and the AMP-activated protein kinase pathway. The findings suggest that tanshinones, particularly dihydrotanshinone I, may offer a pharmacological mechanism for effectively treating inflammatory diseases like septic and gouty inflammation.
Tanshinones, the active ingredients derived from the roots of Salvia miltiorrhiza, have been widely used as traditional medicinal herbs for treating human diseases. Although tanshinones showed anti-inflammatory effects in many studies, large knowledge gaps remain regarding their underlying mechanisms. Here, we identified 15 tanshinones that suppressed the activation of NLRP3 inflammasome and studied their structure-activity relationships. Three tanshinones (tanshinone IIA, isocryptotanshinone, and dihydrotanshinone I) reduced mitochondrial reactive-oxygen species production in lipopolysaccharide (LPS)/nigericin-stimulated macrophages and correlated with altered mitochondrial membrane potentials, mitochondria complexes activities, and adenosine triphosphate and protonated-nicotinamide adenine dinucleotide production. The tanshinones may confer mitochondrial protection by promoting autophagy and the AMP-activated protein kinase pathway. Importantly, our findings demonstrate that dihydrotanshinone I improved the survival of mice with LPS shock and ameliorated inflammatory responses in septic and gouty animals. Our results suggest a potential pharmacological mechanism whereby tanshinones can effectively treat inflammatory diseases, such as septic and gouty inflammation.
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