Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 98, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2021.107909
Keywords
Sepsis; Bacteria; Fungus; Virus; Pattern recognition receptors
Categories
Funding
- [R21 HD099194]
- [R01 GM118277]
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Understanding host immunological responses is crucial in developing appropriate therapeutic approaches for different types of sepsis. Pattern recognition receptors play a key role in bacterial, fungal, and viral sepsis, and have therapeutic potential.
Sepsis remains to be a significant health care problem associated with high morbidities and mortalities. Recognizing its heterogeneity, it is critical to understand our host immunological responses to develop appropriate therapeutic approaches according to the type of sepsis. Because pattern recognition receptors are largely responsible for the recognition of microbes, we reviewed their role in immunological responses in the setting of bacterial, fungal and viral sepsis. We also considered their therapeutic potentials in sepsis.
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