Journal
FITOTERAPIA
Volume 109, Issue -, Pages 236-240Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2016.01.013
Keywords
Baeckea frutescens; Myrtaceae; Phloroglucinols; Cytotoxic activity; Indonesia
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Funding
- Indonesian Ministry of Science and Technology
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Kobayashi International Scholarship Foundation
- Grants-in-Aid for Scientific Research [26460140, 15H05138] Funding Source: KAKEN
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Three new phloroglucinols, baeckenones D-F (1-3), were obtained from the leaves of Indonesian Baeckea frutescens, along with the known unusual endoperoxide, phloroglucinol (4). The structures of the isolated compounds were elucidated by 1D and 2D NMR and FIREIMS spectra. Furthermore, the stereochemistry of baeckenone D (1) was established by an X-ray diffraction analysis. Among the isolated compounds 1-4, baeckenone F (3) showed moderate cytotoxic activities against human pancreatic (PSN-1), lung (A549), and breast (MDA-MB-231) cancer cell lines, with IC50 values of 33.3 mu M, 34 pM, and 39.3 mu M, respectively. (C) 2016 Elsevier B.V. All rights reserved.
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