Journal
FITOTERAPIA
Volume 114, Issue -, Pages 1-6Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2016.08.007
Keywords
Lamiaceae; Salvia amarissima; Clerodane diterpenes; Cytotoxic; MDR modulation
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Three new diterpenes (amarissinins A-C, 1-3) containing several oxygenated functionalities were isolated from the leaves and flowers of Salvia amarissima. The structures of these compounds were established through the analysis of their NMR spectroscopy and mass spectrometry data. The structures of compounds 1 and 2 were confirmed by single crystal X-ray diffraction. Compound 2 was identified as a C-10 epimer of dugesin F (5). The cytotoxic activity of these compounds against five human cancer cell lines was determined. Additionally, the capability to modulate the multidrug resistance (MDR) in the MCF-7 cancer cell line resistant to vinblastine was tested. (C) 2016 Elsevier B.V. All rights reserved.
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