Journal
FITOTERAPIA
Volume 113, Issue -, Pages 6-26Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2016.06.009
Keywords
Phellinus linteus; Phellinus igniarius; Traditional Chinese medicine; Fermentation; Phytochemistry; Pharmacology
Categories
Funding
- Program for the New Century Excellent Talents in University [NCET-13-0954]
- Changjiang Scholars and Innovative Research Team in University from Ministry of Education of China [IRT1174]
- National Natural Science Foundation of China [J1210063, 81202909, 81274025, 81001622]
- project As a Major New Drug to Create a Major National Science and Technology Special [2014ZX09304307-002]
- Key Program for the International S & T Cooperation Projects of Shaanxi Province [2013KW31-01]
- Administration of Traditional Chinese Medicine of Shaanxi [13-ZY006]
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Medicinal mushroom Phellinus linteus (Sanghuang in Chinese) is a famous fungus which is widely used in China, Korea, and other Asian countries. As a traditional Chinese medicine with a 2000-year long history, medicinal applications of Phellinus linteus mainly include treating hemorrhage, hemostasis and diseases related to female menstruation according to Chinese clinical empirical practice. A number of studies reported Phellinus linteus possessed good therapeutic effects on various ailments including tumor, diabetes, inflammation, obesity, etc. The present paper comprehensively reviewed the traditional uses, fermentation, constituent and pharmacology of Phellinus linteus based on scientific literature as well as critical analysis of the research. This review aimed to provide latest information and new foundations and directions for further investigations on Phellinus linteus. All available information about Phellinus linteus was supplied by library database and electronic search (CNKI, Google Scholar, ScienceDirect, Web of Science, PubMed, etc.). Some local and ancient books as well as brilliant scholars were also important information resources. Improvement of fermentation techniques promoted the production of Phellinus linteus. Studies of constituents showed the main chemical composition of Phellinus linteus included polysaccharides, flavones, triterpenes, aromatic acids, amino acids, etc. and polysaccharides were found to account for the largest proportion. Pharmacological researches revealed Phellinus linteus possessed a variety of biological activities including anti-cancer, immuno-regulation, anti-diabetes, anti-oxidation and anti-inflammation. Based on these summarized information, this review was presented to provide helpful references and beneficial directions for future studies of Phellinus linteus. (C) 2016 Elsevier B.V. All rights reserved.
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