Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 98, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2021.107910
Keywords
Vitiligo; Phototherapy; Calcipotriol; Narrowband ultraviolet B; 308 nm excimer laser; Psoralen ultraviolet A
Categories
Funding
- National Natural Science Foundation of China [81872528]
- Natural Science Foundation of Liaoning Province, China [2020-MS-262]
Ask authors/readers for more resources
The combination of phototherapy and topical calcipotriol demonstrates significantly higher efficacy in treating vitiligo compared to phototherapy alone, with minor, transient, and tolerable side effects.
Background: Treatment of vitiligo has several challenges. Phototherapy and topical calcipotriol have been reported to be effective in combination with other therapies, but there is no consensus on the combination use. Objective: To perform a systematic review and meta-analysis that elucidates the efficacy of the combination of phototherapy and topical calcipotriol. Methods: This systematic review was performed by searching PubMed, EMBASE, Web of Science, Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), WanFang and VIP databases for relevant publications till February 28, 2021. Relative risk (RR) and its 95% confidence interval (CI) were used to evaluate the data. Bias assessment, heterogeneity and sensitivity analysis were conducted in this meta-analysis. Results: After screening, nine studies with 700 participants were included. The meta-analysis indicated that the combination of phototherapy and topical calcipotriol showed significantly higher effective rate (RR 1.11, 95% CI 1.02-1.22; p < 0.05) and apparent effective rate (RR 1.35, 95% CI 1.15-1.59; p < 0.01) than phototherapy monotherapy in the treatment of vitiligo. In addition, the side effects were minor, transient and tolerable. Conclusions: This meta-analysis provides evidence supporting phototherapy combined with topical calcipotriol as a valuable treatment modality for patients with vitiligo, which has better efficacy than monotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available