Journal
INTERNAL MEDICINE
Volume 60, Issue 18, Pages 2985-2989Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.6633-20
Keywords
childhood-onset steroid-dependent nephrotic syndrome; focal segmental glomerulosclerosis; pregnancy; rituximab; safety use
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Rituximab may be safely used in pregnant women with complicated SDNS. A woman with childhood-onset complicated SDNS due to focal and segmental glomerulosclerosis had two successful pregnancies while receiving RTX maintenance therapy, with no adverse complications observed during the pregnancies.
There are an increasing number of reports on the safe use of rituximab (RTX), a chimeric anti-CD20 monoclonal antibody, in pregnant women with hematological malignancies or refractory autoimmune diseases. In 2014, the use of RTX for patients with complicated steroid-dependent nephrotic syndrome (SDNS) was approved in Japan. We herein report a woman with childhood-onset complicated SDNS due to focal and segmental glomerulosclerosis, who had two successful pregnancies while receiving RTX maintenance therapy. No adverse complications were observed during the pregnancies, and she delivered healthy newborns. This case suggested that RTX may be used safely in pregnant women complicated with SDNS.
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