Journal
FITOTERAPIA
Volume 110, Issue -, Pages 77-82Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2016.02.005
Keywords
Bipolaris sorokiniana; Endophytic fungus; Pogostemon cablin; Cochlioquinones; Cytotoxic activity
Categories
Funding
- National Basic Research Program of China (973 Program) [2014CB460613]
- National Natural Science Foundation of China [81203006]
- Natural Science Foundation of Guangdong Province [2015 A030313710]
- Guangdong Provincial Project for Science and Technology [2015 A030302060]
Ask authors/readers for more resources
Chemical investigation of the liquid culture of the endophytic fungus Bipolaris sorokiniana A606, which was isolated from the medicinal plant Pogostemon cablin resulted in the isolation of four new cytotoxic compounds, named isocochlioquinones D-E (1-2) and cochlioquinones G-H (3-4), along with five known cochlioquinone analogues (5-9). Their structures were determined on the basis of extensive spectroscopic analysis. Isocochlioquinone D (1) possessed a rare benzothiazin-3-one moiety and cochlioquinone G (3) was the first example of cochlioquinones beating an indole-4,7-dione fragment. All of the isolates (1-9) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, SF-268 and HepG-2 tumor cell lines by the sulforhodamine B (SRB) assay. Compounds 4 and 6-9, featuring a cochlioquinone core, exhibited potent cytotoxicities in vitro against the four tumor cell lines, and a preliminary structure-activity relationship of these compounds was also discussed. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available