Synthesis, X-ray structure and biological activity of mono- and dinuclear copper complexes derived from N-{2-[(2-diethylamino(alkyl) imino)-methyl]-phenyl}-4-methyl-benzenesulfonamide

A series of copper(II) complexes with new Schiff bases, namely N-{2-[(2-diethylamino(alkyl)imino)-methyl]phenyl}-4-methylbenzenesulfonamide [alkyl = ethyl (HL1) or propyl (HL2)], were synthesized using copper acetate or chloride and characterized by elemental analysis, IR and X-ray absorption spectroscopy, and singlecrystal X-ray diffraction. The coordination geometry around the Cu(II) ion in Cu(L1)2 and Cu(L2)2 was studied by X-ray absorption spectroscopy. The crystal structures of copper(II) complexes with L1 ligand synthesized from copper chloride and copper acetate with addition of sodium azide have been determined by X-ray diffraction. The azomethines and all copper(II) complexes have been screened for their antibacterial, protistocidal, and fungistatic activities against Penicillium italicum, Colpoda steinii, Escherichia coli 078, and Staphylococcus aureus P209.

Automated summary

A series of new copper(II) complexes with Schiff bases were synthesized and characterized, and their antibacterial, protistocidal, and fungistatic activities were screened. The complexes were characterized by various methods and their crystal structures were studied.