Self-Assembly and Multifaceted Bioactivity of a Silver(I) Quinolinate Coordination Polymer

Coordination polymers have emerged as a new class of potent biologically active agents due to a variety of important characteristics such as the presence of bioactive metal centers and linkers, low toxicity, stability, tailorable structures, and bioavailability. The research on intermediate metabolites has also been explored with implications toward the development of selective anticancer, antimicrobial, and antiviral therapeutic strategies. In particular, quinolinic acid (H(2)quin) is a recognized metabolite in kynurenine pathway and potent neurotoxic molecule, which has been selected in this study as a bioactive building block for assembling a new silver(I) coordination polymer, [Ag(Hquin)(mu-PTA)](n)center dot H2O (1). This product has been prepared from silver oxide, H(2)quin, and 1,3,5-triaza-7-phosphaadamantane (PTA), and fully characterized by standard methods including single-crystal X-ray diffraction. Compound 1 has revealed distinctive bioactive features, namely (i) a remarkable antiviral activity against herpes simplex virus type 1 (HSV-1) and adenovirus 36 (Ad-36), (ii) a significant antibacterial activity against clinically important bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), and (iii) a selective cytotoxicity against HeLa (human cervix carcinoma) cell line. The present work widens a growing family of bioactive coordination polymers with potent antiviral, antibacterial, and antiproliferative activity.

Automated summary

Coordination polymers with bioactive metal centers and linkers, low toxicity, stability, tailorable structures, and bioavailability have emerged as a new class of potent biologically active agents. Quinolinic acid, a potent neurotoxic metabolite, has been utilized as a building block to assemble a new silver(I) coordination polymer with distinctive bioactive features, exhibiting remarkable antiviral, antibacterial, and selective cytotoxic activities. This study expands the family of bioactive coordination polymers with potent antiviral, antibacterial, and antiproliferative activity.