The rationale behind implant coatings to promote osteointegration, bone healing or regeneration

Implant loosening, bone healing failure, implant-associated infections, and large bony defects remain challenges in orthopedic surgery. Implant surface modifications and coatings are being developed to pro-mote osteointegration, prevent colonization by bacteria, and release bioactive factors. The following mini-review briefly discusses the clinical problem, explains the four osteos, presents examples of coatings used for different orthopedic indications, and finally raises awareness of the coating and translational requirements. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Automated summary

This article discusses the use of implant surface modifications and coatings in orthopedic surgery to address issues such as implant loosening, bone healing failure, infections, and large bony defects.