4.7 Article

A Cervical Histopathology Dataset for Computer Aided Diagnosis of Precancerous Lesions

Journal

IEEE TRANSACTIONS ON MEDICAL IMAGING
Volume 40, Issue 6, Pages 1531-1541

Publisher

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2021.3059699

Keywords

Histopathology; Lesions; Cancer; Annotations; Supervised learning; Feature extraction; Image segmentation; Cervical histopathology; classification; dataset; segmentation; weakly supervised learning

Funding

  1. National Natural Science Foundation of China (NSFC) [U1931202, 62076033]
  2. Beijing Municipal Science and Technology Commission [Z201100007520001, Z131100004013036]
  3. BUPT Excellent Ph.D.
  4. Students Foundation [CX2019217]

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This study introduces a new cervical histopathology image dataset for automated precancerous diagnosis and demonstrates the feasibility of computer aided diagnosis through extensive experiments and methods. The proposed weakly supervised ensemble algorithm shows effectiveness in improving performance.
Cervical cancer, as one of the most frequently diagnosed cancers worldwide, is curable when detected early. Histopathology images play an important role in precision medicine of the cervical lesions. However, few computer aided algorithms have been explored on cervical histopathology images due to the lack of public datasets. In this article, we release a new cervical histopathology image dataset for automated precancerous diagnosis. Specifically, 100 slides from 71 patients are annotated by three independent pathologists. To show the difficulty of the task, benchmarks are obtained through both fully and weakly supervised learning. Extensive experiments based on typical classification and semantic segmentation networks are carried out to provide strong baselines. In particular, a strategy of assembling classification, segmentation, and pseudo-labeling is proposed to further improve the performance. The Dice coefficient reaches 0.7833, indicating the feasibility of computer aided diagnosis and the effectiveness of our weakly supervised ensemble algorithm. The dataset and evaluation codes are publicly available. To the best of our knowledge, it is the first public cervical histopathology dataset for automated precancerous segmentation. We believe that this work will attract researchers to explore novel algorithms on cervical automated diagnosis, thereby assisting doctors and patients clinically.

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