Journal
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
Volume 27, Issue 5, Pages -Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2021.3055078
Keywords
Optofluidics; Integrated waveguides; Fluorescence; Signal enhancement; Limit-of-detection
Categories
Funding
- NIH [1R01EB028608, 1R01AI116989]
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The study introduced a new optofluidic platform based on silicon photonics, achieving higher detection efficiency and lower detection limits. This platform demonstrated ultra-high sensitivity for analyzing pathogens at clinical concentrations, marking a significant step towards developing an ultrasensitive biosensor system.
High sensitivity and easy integration with microfabrication techniques has made silicon photonics one of the leading technologies used to build biosensors for diagnostic applications. Here we introduce a new silicon dioxide based optofluidic platform having a planar solid-core (SC) waveguide orthogonally intersecting a liquid-core (LC) waveguide with high refractive index ZnI2 salt solution as core. This enables both more uniform collection of particle fluorescence by the core mode and its propagation to an off-chip detector. This approach results in ultra-high sensitivity performance, demonstrated by achieving 8X enhancement in signal-to-noise ratio, a 45x increase in detection efficiency, and a 100x lower detection limit of 80 aM of fluorescent nanobeads. This represents a key step towards an ultrasensitive biosensor system for analyzing pathogens at clinical concentrations.
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