Journal
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
Volume 27, Issue 5, Pages -Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2021.3083687
Keywords
Probes; Raman scattering; Spectrogram; Automobiles; Sodium; Oils; Ultrafast optics; Biomedical imaging; raman scattering; nonlinear optics; time-domain analysis
Categories
Funding
- National Science Foundation [DBI-1455671, ECCS-1509268, CMMI-1826078]
- Air Force Office of Scientific Research [FA9550-15-1-0517, FA955020-1-0366, FA9550-20-1-0367]
- National Institutes of Health [1R01GM127696-01, 1R21 GM142107-01]
- DOD Army Medical Research program [W81XWH2010777]
- Cancer Prevention and Research Institute of Texas [RP180588]
- National Science Foundation of China [11934011, 11874322]
- National Key Research and Development Program of China [2019YFA0308100, 2018YFA0307200]
- Zhejiang Province Key Research and Development Program Award [2020C01019]
- Zhejiang University
- Information Technology Center of Zhejiang University
- Fundamental Research Funds for the Central Universities of China
- Major Scientific Research Project of Zhejiang Lab [2019MB0AD01, 20190057]
- U.S. Department of Defense (DOD) [W81XWH2010777] Funding Source: U.S. Department of Defense (DOD)
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Raman spectroscopy provides a non-invasive, chemically-specific optical imaging of biological objects without using endogenous labels. Nonlinear Raman spectroscopy allows faster imaging with improved spatial resolution and axial sectioning capability. The report introduces a novel use of nonlinear Raman spectroscopy as a sensor of local nano-environment, where time-resolved coherent anti-Stokes Raman spectrograms are sensitive to small variations in local structural changes not normally observed with conventional Raman spectroscopy.
Raman spectroscopy provides a non-invasive, chemically-specific optical imaging of biological objects without relying on endogenous labels. Nonlinear Raman spectroscopy allows non-invasive imaging at much faster speed with an improved spatial resolution and axial sectioning capability. In this report we propose a novel use of nonlinear Raman spectroscopy as a sensor of local nano-environment. Time-resolved coherent anti-Stokes Raman spectrograms are found to be sensitive to small variations of local structural changes, which are not normally observed using conventional Raman spectroscopy.
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