4.5 Article

The vitamin A transporter STRA6 adjusts the stoichiometry of chromophore and opsins in visual pigment synthesis and recycling

Related references

Note: Only part of the references are listed.
Review Ophthalmology

Molecular components affecting ocular carotenoid and retinoid homeostasis

Johannes von Lintig et al.

Summary: The photochemistry of vision involves opsins and the isomerization of their retinylidine chromophores. Different animal classes use distinct G proteins to regulate the photoreceptor membranes. Vertebrates utilize retinoic acid as a ligand for nuclear hormone receptors, while obtaining carotenoids from diet and metabolizing them. Recent advancements have led to a better understanding of carotenoid metabolism and its impact on ocular pathologies.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

Review Biochemistry & Molecular Biology

Carotenoid metabolism at the intestinal barrier

Johannes von Lintig et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)

Review Biochemistry & Molecular Biology

The molecular aspects of absorption and metabolism of carotenoids and retinoids in vertebrates

Made Airanthi K. Widjaja-Adhi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)

Article Multidisciplinary Sciences

Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport

Ming Zhong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Medicine, General & Internal

Targeting of the NRL Pathway as a Therapeutic Strategy to Treat Retinitis Pigmentosa

Spencer M. Moore et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Ophthalmology

Mouse Cones Adapt Fast, Rods Slowly In Vivo

Anneka Joachimsthaler et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2019)

Article Pharmacology & Pharmacy

Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration

Songqi Gao et al.

MOLECULAR PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration

Aswin Pyakurel et al.

MOLECULAR AND CELLULAR BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Transport of vitamin A across blood-tissue barriers is facilitated by STRA6

Mary Kelly et al.

FASEB JOURNAL (2016)

Article Nutrition & Dietetics

Biomarkers of Nutrition for Development (BOND)-Vitamin A Review

Sherry A. Tanumihardjo et al.

JOURNAL OF NUTRITION (2016)

Article Multidisciplinary Sciences

Structure of the STRA6 receptor for retinol uptake

Yunting Chen et al.

SCIENCE (2016)

Review Chemistry, Multidisciplinary

Chemistry of the Retinoid (Visual) Cycle

Philip D. Kiser et al.

CHEMICAL REVIEWS (2014)

Article Biochemistry & Molecular Biology

STRA6 is critical for cellular vitamin A uptake and homeostasis

Jaume Amengual et al.

HUMAN MOLECULAR GENETICS (2014)

Article Medicine, Research & Experimental

Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration

Yu Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Nutrition & Dietetics

A global clinical view on vitamin A and carotenoids

Alfred Sommer et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2012)

Article Biochemistry & Molecular Biology

Lecithin: Retinol Acyltransferase Is Critical for Cellular Uptake of Vitamin A from Serum Retinol-binding Protein

Jaume Amengual et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Receptor-Mediated Cellular Uptake Mechanism That Couples to Intracellular Storage

Riki Kawaguchi et al.

ACS CHEMICAL BIOLOGY (2011)

Review Nutrition & Dietetics

Vitamin A Metabolism: An Update

Diana N. D'Ambrosio et al.

NUTRIENTS (2011)

Article Ophthalmology

Comparison of Ocular Pathologies in Vitamin A-Deficient Mice and RPE65 Gene Knockout Mice

Yang Hu et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Article Biochemistry & Molecular Biology

In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death

Marijana Samardzija et al.

HUMAN MOLECULAR GENETICS (2009)

Article Biochemistry & Molecular Biology

Retinopathy in mice induced by disrupted all-trans-retinal clearance

Akiko Maeda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A

Riki Kawaguchi et al.

SCIENCE (2007)

Article Ophthalmology

Cone opsin mislocalization in Rpe65-/- mice:: A defect that can be corrected by 11-cis retinal

B Rohrer et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)

Article Neurosciences

Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice

J Fan et al.

JOURNAL OF PHYSIOLOGY-LONDON (2005)

Article Multidisciplinary Sciences

Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle

TM Redmond et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver

ML Batten et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Nutrition & Dietetics

Vitamin A: Overlapping delivery pathways to tissues from the circulation

J Paik et al.

JOURNAL OF NUTRITION (2004)

Article Genetics & Heredity

Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis

ML Woodruff et al.

NATURE GENETICS (2003)

Review Biochemistry & Molecular Biology

Phototransduction: crystal clear

KD Ridge et al.

TRENDS IN BIOCHEMICAL SCIENCES (2003)

Article Biochemistry & Molecular Biology

Retinol-binding protein-deficient mice: Biochemical basis for impaired vision

S Vogel et al.

BIOCHEMISTRY (2002)

Review Ophthalmology

Molecular evolution of vertebrate visual pigments

S Yokoyama

PROGRESS IN RETINAL AND EYE RESEARCH (2000)

Article Endocrinology & Metabolism

Effect of stanol ester on postabsorptive squalene and retinyl palmitate

H Relas et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2000)