Temporal dynamic of the hippocampal structural plasticity associated with the fear memory destabilization/reconsolidation process

Reconsolidation of a contextual fear memory is a protein synthesis-dependent process in which a previously destabilized memory returns to a stable state. This process has become the subject of many studies due to its importance in memory processing, maintenance and updating, and its potential role as a therapeutical target in fear memory disorders such as phobias and post-traumatic stress disorder. In this sense, understanding the underlying mechanisms of memory reconsolidation is paramount in developing potential treatments for such memory dysfunctions. In the present work, we studied the interaction between two key neural structures involved in the reconsolidation process: the basolateral amygdala complex of the amygdala (BLA) and the dorsal hippocampus (DH). Our results show changes in the structural plasticity of the CA1 region of the DH in the form of dendritic spines density changes associated with the destabilization/reconsolidation process. Furthermore, we demonstrate a modulatory role of BLA over such structural plasticity by infusing different drugs such as ifenprodil, a destabilization blocker, and propranolol, a reconsolidation disruptor, in this brain structure. Altogether our work shows a particular temporal dynamic in the CA1 region of DH that accompanies the destabilization/reconsolidation process and aims to provide new information on the underlying mechanisms of this process that potentially contributes for a better understanding of memory storage, maintenance, expression and updating, and its potential medical applications.

Automated summary

The reconsolidation of fear memory is a protein synthesis-dependent process wherein destabilized memory returns to a stable state, attracting extensive studies for its implications in memory processing and potential therapeutic applications. This study focused on the interaction between the BLA and DH, showing changes in structural plasticity in the DH's CA1 region during the destabilization/reconsolidation process. Additionally, the modulatory role of BLA in structural plasticity was demonstrated through drug infusions, offering insights into the underlying mechanisms of memory storage and potential medical applications.