Temperature dependence of spontaneous mutation rates

Mutation is the source of genetic variation and the fundament of evolution. Temperature has long been suggested to have a direct impact on realized spontaneous mutation rates. If mutation rates vary in response to environmental conditions, such as the variation of the ambient temperature through space and time, they should no longer be described as species-specific constants. By combining mutation accumulation with whole-genome sequencing in a multicellular organism, we provide empirical support to reject the null hypothesis of a constant, temperature-independent mutation rate. Instead, mutation rates depended on temperature in a U-shaped manner with increasing rates toward both temperature extremes. This relation has important implications for mutation-dependent processes in molecular evolution, processes shaping the evolution of mutation rates, and even the evolution of biodiversity as such.

Automated summary

Mutation serves as the source of genetic variation and foundation of evolution, with temperature directly impacting spontaneous mutation rates. The variation of mutation rates in response to environmental conditions follows a U-shaped pattern in relation to temperature. This has significant implications for mutation-dependent processes in molecular evolution, the evolution of mutation rates, and biodiversity evolution.