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Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
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Hotspot Mutation Panel Testing Reveals Clonal Evolution in a Study of 265 Paired Primary and Metastatic Tumors
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CLINICAL CANCER RESEARCH (2015)
Targeting cancer-specific mutations by T cell receptor gene therapy
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CURRENT OPINION IN IMMUNOLOGY (2015)
Is right-sided colon cancer different to left-sided colorectal cancer? - A systematic review
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Vascular Endothelial Growth Factor C Disrupts the Endothelial Lymphatic Barrier to Promote Colorectal Cancer Invasion
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Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
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PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
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Sequential cancer mutations in cultured human intestinal stem cells
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Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids
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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
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NEW ENGLAND JOURNAL OF MEDICINE (2015)
The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
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Tissue Inhibitor of Metalloproteinases (TIMP)-1 Creates a Premetastatic Niche in the Liver Through SDF-1/CXCR4-Dependent Neutrophil Recruitment in Mice
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Nathan R. West et al.
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Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
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Microbes, Microbiota, and Colon Cancer
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Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer
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Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK
Philip W. Voorneveld et al.
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γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer
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IMMUNITY (2014)
Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis
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Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
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A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth
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Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells
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ArhGAP30 promotes p53 acetylation and function in colorectal cancer
Jilin Wang et al.
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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
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mTOR pathway in colorectal cancer: an update
Maria Giovanna Francipane et al.
ONCOTARGET (2014)
MYC and the Control of Apoptosis
Steven B. McMahon
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2014)
Dendritic cell defects in the colorectal cancer
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HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)
Stem cell dynamics in homeostasis and cancer of the intestine
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A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis
C. C. J. M. Simons et al.
ANNALS OF ONCOLOGY (2013)
Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer
R. Bertorelle et al.
BRITISH JOURNAL OF CANCER (2013)
Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors
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A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
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T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer
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VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer
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Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
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IDO1 Metabolites Activate β-catenin Signaling to Promote Cancer Cell Proliferation and Colon Tumorigenesis in Mice
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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts
Simon J. Leedham et al.
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Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
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Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
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Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis
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Dclk1 distinguishes between tumor and normal stem cells in the intestine
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Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
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SCIENCE TRANSLATIONAL MEDICINE (2013)
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
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Serine, glycine and one-carbon units: cancer metabolism in full circle
Jason W. Locasale
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Direct molecular interactions between HMGB1 and TP53 in colorectal cancer
Kristen M. Livesey et al.
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Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia
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p53/HMGB1 Complexes Regulate Autophagy and Apoptosis
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Tumor-associated neutrophils: friend or foe?
Zvi G. Fridlender et al.
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On the dual roles and polarized phenotypes of neutrophils in tumor development and progression
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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Aleksandar D. Kostic et al.
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Discoidin domain receptor 2 deficiency predisposes hepatic tissue to colon carcinoma metastasis
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Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity
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NF-κB inhibition delays DNA damage-induced senescence and aging in mice
Jeremy S. Tilstra et al.
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Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon
Makoto Kinoshita et al.
JOURNAL OF IMMUNOLOGY (2012)
Contribution of Behavioral Risk Factors and Obesity to Socioeconomic Differences in Colorectal Cancer Incidence
Chyke A. Doubeni et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2012)
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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
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Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells
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Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
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Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling
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EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF-Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib
Ryan B. Corcoran et al.
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AHR and the transcriptional regulation of type-17/22 ILC
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Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair-Deficient Cancers
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MRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers
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Tumor-Associated Neutrophils: New Targets for Cancer Therapy
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GENES CHROMOSOMES & CANCER (2011)
β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
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Dale C. Snover
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IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
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Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras
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Single-cell dissection of transcriptional heterogeneity in human colon tumors
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NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2011)
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
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Neutrophils in the activation and regulation of innate and adaptive immunity
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DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1
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Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
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Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
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Enterotoxigenic Bacteroides fragilis (ETBF)-mediated colitis in Min (Apc(+/-)) mice A human commensal-based murine model of colon carcinogenesis
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CELL CYCLE (2010)
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Inflammation and Colon Cancer
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GASTROENTEROLOGY (2010)
Tumor necrosis is a new promising prognostic factor in colorectal cancer
Marion J. Pollheimer et al.
HUMAN PATHOLOGY (2010)
Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8
Ahmed S. Abdulamir et al.
MOLECULAR CANCER (2010)
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
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NATURE CELL BIOLOGY (2010)
The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection
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Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation
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Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype, and Increased Sensitivity to Insulin-like Growth Factor-I Receptor Inhibition
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A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-κB-signaling pathways
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A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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Christoph A. Klein
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Relationship Between Tumor and Plasma Levels of hTERT mRNA in Patients with Colorectal Cancer: Implications for Monitoring of Neoplastic Disease
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Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
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Identification of stem cells in small intestine and colon by marker gene Lgr5
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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
Jayne M. Stommel et al.
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Binding of Ras to phosphoinositide 3-kinase p110α is required for Ras-driven tumorigenesis in mice
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Inhibitory effect of tumor cell-derived lactic acid on human T cells
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Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse
Christine M. Khoo et al.
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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
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APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression
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Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
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Sarah Edkins et al.
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IL-23 promotes tumour incidence and growth
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p53 regulates mitochondrial respiration
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IL-10 deficiency leads to somatic mutations in a model of IBD
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Telomere length in the colon declines with age: a relation to colorectal cancer?
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TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
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NFκB:: Linking inflammation and immunity to cancer development and progression
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Shelterin: the protein complex that shapes and safeguards human telomeres
T de Lange
GENES & DEVELOPMENT (2005)
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
BA He et al.
ONCOGENE (2005)
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ANNALS OF ONCOLOGY (2005)
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INTERNATIONAL JOURNAL OF CANCER (2004)
Implications of oxidative stress and cell membrane lipid peroxidation in human cancer (Spain)
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IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
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Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose
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Osteopontin regulates multiple functions contributing to human colon cancer development and progression
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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
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Mutagenicity, toxicity and repair of DNA base damage induced by oxidation
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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
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Selective degradation of oxidatively modified protein substrates by the proteasome
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Are there two sides to colorectal cancer?
B Iacopetta
INTERNATIONAL JOURNAL OF CANCER (2002)
Chromosomal instability in ulcerative colitis is related to telomere shortening
JN O'Sullivan et al.
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Tumorigenesis -: RAF/RAS oncogenes and mismatch-repair status
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VEGF-Trap: A VEGF blocker with potent antitumor effects
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Mutations of the BRAF gene in human cancer
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