4.7 Article

Molecular mechanisms underlying health benefits of tea compounds

Journal

FREE RADICAL BIOLOGY AND MEDICINE
Volume 172, Issue -, Pages 181-200

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2021.06.006

Keywords

Food; Medicinal plant; Natural antioxidant; Extraction; Resource

Funding

  1. National Key R&D Program of China [2018YFC1604405]
  2. National Agricultural Science and Technology Center, Chengdu [NASC2020AR02]
  3. China Central Public-interest Scientific Institution Basal Research Fund [Y2020XK05]

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Tea is popular not only for its unique flavor but also for its various health benefits, including antioxidant, anticancer, lipid-lowering, and heart-protective properties. Research has shown that the bioactive components in tea have positive effects on cardiovascular diseases, cancer, and other health issues, making them potential dietary supplements and natural medicines.
Tea is one of the three most widely consumed beverages in the world, not only because of its unique flavor but also due to its various health benefits. The bioactive components in tea, such as polyphenols, polysaccharides, polypeptides, pigments, and alkaloids, are the main contributors to its health functions. Based on epidemiological surveys, the consumption of tea and its compounds in daily life has positive effects on cardiovascular diseases, cancers, hepatopathy, obesity, and diabetes mellitus. In experimental studies, the antioxidant, antiinflammatory, anti-cancer, anti-obesity, cardiovascular protective, liver protective, and hypoglycemic activities of tea and the related mechanisms of action have been widely investigated. The regulation of several classical signaling pathways, such as nuclear factor-Kappa B (NF-Kappa B), AMP activated protein kinase (AMPK), and wingless/integrated (Wnt) signaling, is involved. Clinical trials have also demonstrated the potential of tea products to be applied as dietary supplements and natural medicines. In this paper, we reviewed and discussed the recent literature on the health benefits of tea and its compounds, and specifically explored the molecular mechanisms involved.

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