Journal
FOOD RESEARCH INTERNATIONAL
Volume 147, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2021.110530
Keywords
Spirulina platensis polysaccharides; Lipid and carbohydrate metabolism disorder; mRNA expression; Short-chain fatty acid; Intestinal microbiota
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Funding
- 13th Five-year Plan on Fuzhou Marine Economic Innovation and Development Demonstration City Project [FZHJ17]
- National Natural Science Foundation of China [81741163]
- Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae Grant [2017FZSK05]
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Oral administration of Spirulina platensis crude polysaccharides can significantly improve lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats, along with regulating liver mRNA expressions and modulating intestinal microbiota.
This study aimed to evaluate the possibility that Spirulina platensis crude polysaccharides may ameliorate the lipid and carbohydrate metabolism disorder, including obesity, hyperlipidemia, hyperglycemia, hepatic steatosis, and gut dysbiosis. The results showed Spirulina platensis crude polysaccharides could improve body weight, serum/liver lipid and carbohydrate indexes, and liver antioxidant parameters in high-sucrose and high-fat diet (HFD)-fed rats, which were accompanied by regulated liver mRNA expressions involved in lipid and carbohydrate metabolism disorder. In addition, SPLP intervention significantly decreased cecal level of propionic acid in HFD-fed rats. Notably, the SPLP could alter the relative abundance of Firmicutes, Bacteroides, Proteobacteria, and Actinobacteria at phylum levels. Based on Spearman's rank correlation coefficient, serum/liver lipid and carbohydrate profiles were found significantly positively correlated with genera Romboutsia, Allobaculum, Blautia, Phascolarctobacterium, Bifidobacterium, Coprococcus, Turicibacter, Erysipelotrichaceae_unclassified, Olsenella, Escherichia/Shigella, Coprobacillus, Lachnospiracea incertae, and Lactobacillus, but strongly negatively correlated with genera Atopostipes, Flavonifractor, Porphyromonadaceae_unclassified, Barnesiella, Oscillibacter, Paraprevotella, Jeotgalicoccus, Corynebacterium, Alloprevotella and Bacteroides. It was concluded that oral administration of SPLP could remarkably ameliorate the lipid and carbohydrate metabolism disorder and significantly modulate the intestinal microbiota in HFD-fed rats.
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