Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 154, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112314
Keywords
NAFLD; Quercetin; GEO database; Hepatoprotection
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Funding
- National Natural Science Foundation of China [81872619]
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Quercetin, a polyphenol found in plants, has shown hepatoprotective effects against NAFLD, particularly in hepatic steatosis and hepatitis, through mechanisms such as improving fatty acid metabolism and anti-inflammation. Further research based on GEO database and experimental evidence has discussed the pathways of quercetin on NAFLD comprehensively.
Quercetin, a polyphenol widely present in the plant kingdom, has received great interest due to pleiotropic effects. As evidenced by animal and cellular studies, quercetin exerts hepatoprotection against non-alcoholic fatty liver disease (NAFLD), particularly in hepatic steatosis and hepatitis. Mechanically, various hypotheses of such protective effects have been actively proposed, including improving fatty acid metabolism, anti-inflammation, anti-oxidant, modulating gut microbiota and bile acid, etc. Here, the role of quercetin in NAFLD was summarized. With a particular focus on molecular mechanism, we comprehensively discussed the pathways of quercetin on NAFLD based on the analysis from Gene Expression Omnibus (GEO) database and experimental evidence.
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