Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 155, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112376
Keywords
Meat hydrolysates; Maillard reaction; Drosophila; Antioxidant; Anti-aging
Categories
Funding
- Key Laboratory of Refrigeration and Conditioning Aquatic Products Processing, Ministry of Agriculture and Rural Affairs, China [KLRCAPP2021-03]
- Central Government Guided Local Science and Technology Development Project, China [2020L3004]
- Fuzhou Science & Technology Project, China [2020-GX-8]
- Fujian Major Project of Provincial Science & Technology Hall, China [2020NZ010008]
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The study demonstrated that CMP-MRP obtained through Maillard reaction showed remarkable antioxidant and anti-aging capacities in Drosophila models, improving lifespan, athletic ability, and reducing oxidative stress markers. The results suggest that CMP-MRP has great potential as a food-derived anti-aging agent in health food and biomedicine fields.
With the aging problems increasing, the discovery of anti-aging compounds has become a popular research direction. Accumulation of free radicals and the consequent oxidative stress are the chief culprit of aging. Given this, cultured crocodile meat peptides-Maillard reaction product (CMP-MRP) with remarkable antioxidant activity was obtained via Maillard reaction of cultured crocodile meat hydrolysates and xylose. The antioxidant activity in vitro and anti-aging activity in vivo of CMP-MRP were investigated. Results indicated that the lifespan and the athletic ability of Drosophila were significantly improved after the administration of CMP-MRP in natural aging, H2O2- and paraquat-induced models. Furthermore, the antioxidant enzyme activities of Drosophila treated with CMP-MRP were enhanced while the levels of malondialdehyde (MDA) and protein carbonyl (PCO) were reduced in three Drosophila models. With the supplement of 5 mg/mL CMP-MRP in natural aging Drosophila model, the maximum lifespan increased from 61 days to 73 days, athletic ability raised by 95.45%, MDA and PCO reduced by 52.72% and 47.43%, respectively. Taken together, CMP-MRP exhibited outstanding antioxidant and anti-aging capacities in Drosophila models, suggesting that CMP-MRP possesses great potential in the health food and biomedicine fields as a food-derived anti-aging agent.
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