Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 153, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112310
Keywords
Genetically modified wheat; DREB3; Reproduction toxicity; Rats
Categories
Funding
- major science and technology project for cultivation of new crop varieties using gene transfer technology
- Ministry of Agriculture of the People's Republic of China [2014ZX08011005, 2016ZX08011005]
- GM wheat and non-GM wheat (Jimai22)
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In a two-generation reproductive toxicology study, no adverse effects related to gene modified wheat were observed in rats compared to non-gene modified wheat, indicating that gene modified wheat is a safe alternative in terms of reproductive toxicity.
To study reproductive toxicity of gene modified wheat generated by introducing DREB3 (drought response element binding protein 3) gene, Wistar rats of were allocated into 3 groups and fed with DREB3 gene modified wheat mixture diet (GM group), non-gene modified wheat mixture diet (Non-GM group) and AIN-93 diet (Control group) from parental generation (F0) to the second offspring (F2). GM wheat and Non-GM wheat, Jimai22, were both formulated into diets at a ratio of 69.55% according to AIN93 diet for rodent animals. Compared with non-GM group, no biologically related differences were observed in GM group rats with respect to reproductive performance such as fertility rate, gestation rate, mean duration, hormone level, reproductive organ pathology and developmental parameters such as body weight, body length, food consumption, neuropathy, behavior, immunotoxicity, hematology and serum chemistry. In conclusion, no adverse effect were found relevant to GM wheat in the two generation reproduction toxicity study, indicating the GM wheat is a safe alternative for its counterpart wheat regarding to reproduction toxicity.
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