Journal
FITOTERAPIA
Volume 153, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2021.104959
Keywords
Hypericum forrestii (Chittenden) N Robson; Clusiaceae; Acylphloroglucinol meroterpenoid; Hyperiforins A-C; Protein tyrosine phosphatase 1B
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Funding
- National Natural Science Foundation of China [21672040, 82073717]
- Science and Technology Commission of Shanghai Municipality [20S21900600]
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Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C, were isolated from Hypericum forrestii, along with twelve known analogues. Among them, compounds 1, 2, 5, 7, and 13-15 exhibited potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values ranging from 6.63 +/- 2.40 to 14.21 +/- 3.51 μM.
Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C (1-3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4-15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13-15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values from 6.63 +/- 2.40 to 14.21 +/- 3.51 is mu M.
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