Journal
FITOTERAPIA
Volume 151, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2021.104874
Keywords
Salvia miltiorrhiza; Chaetomium globosum D38; Chaetoglobosins; Cytotoxic activities; NO production inhibitory effects
Categories
Funding
- Shanghai Risingstar Program [18QA1405200]
- Program of Shanghai Health System Subject Chief Scientist [2017BR004]
- National High Technology Research and Development Program of China [2014AA 020508]
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Two new 19,20-seco-chaetoglobosins, salchaetoglobosins A and B, along with three known analogues, were isolated from the solid rice culture of Chaetomium globosum D38, an endophytic fungus derived from Salvia miltiorrhiza, and their structures and biological activities were evaluated.
Chemical investigation on the solid rice culture of Chaetomium globosum D38, an endophytic fungus derived from Salvia miltiorrhiza, has afforded two new 19,20-seco-chaetoglobosins, salchaetoglobosins A (1) and B (2), along with three known analogues, chaetoglobosins E (3), Fex (4), and Vb (5). Their structures and absolute configurations were elucidated by a set of spectroscopy and single-crystal X-ray crystallography. Compounds 1-5 were evaluated for their cytotoxic activities against HCT-116 (colorectal carcinoma) and PC3 (prostate cancer) cells, as well as the NO production inhibitory effects in LPS-stimulated RAW264.7 cells.
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