Sesquiterpenoids with neuroprotective activities from the Chloranthaceae plant Chloranthus henryi

A rare sesquiterpenoid possessing a 6/6 bicyclic system fused with two clustered furan units and a pair of guaiane-type sesquiterpenoids were acquired from the roots of Chloranthus henryi. Their structures with absolute configurations were characterized with spectroscopic data, ECD, and X-ray diffraction analysis. All three sesquiterpenoids showed moderate neuroprotective activities on PC12 cells damaged with hydrogen peroxide.

Automated summary

Three rare sesquiterpenoids with unique structures were isolated from the roots of Chloranthus henryi, showing moderate neuroprotective activities on PC12 cells damaged with hydrogen peroxide through experimental studies.