Single-step Synthesis and Characterization of Zr-MOF onto Wool Fabric: Preparation of Antibacterial Wound Dressing with High Absorption Capacity

Improvement of curative herbal extracts effectiveness through novel drug delivery systems is a field of study for the researches nowadays. Zirconium-based metal-organic frameworks (Zr-MOFs) are one of the most capable porous nanocarriers that need a biocompatible template to be used in biomedical applications. In this work, Zr-MOF was synthesized into the wool fabric through in-situ one-pot method with different molar ratios. The final fabrics were characterized thoroughly using various techniques and the effect of components on monodispersity and nucleation tendency of Zr-MOF onto the surface of wool were explained. The resultant fabric stablished absolute wash durability, increased air-permeability up to twice and reasonable hydrophilicity. Tensile strength and young modulus decreased 30 and 1244 % and strain increased 66 %. Salvia Officinalis (SO) and Calendula Officinalis (CO) extracts were loaded onto the modified fabrics with 1154 and 1842 % increased absorption capacity. The release profiles showed domination of diffusion mechanism. The wool-MOF-SO and CO displayed both 100 % antibacterial activity against Escherichia coli and 60.95 and 64.64 % against Staphylococcus aureus because of diverse antibacterial components. Calendula Officinalis proved biocompatibility with human skin however Salvia Officinalis exhibited high toxicity.

Automated summary

Enhancing the effectiveness of curative herbal extracts through novel drug delivery systems is a current research focus. Zr-MOF was synthesized into wool fabric, resulting in improved wash durability and increased absorption capacity. After loading SO and CO extracts, the fabrics exhibited 100% antibacterial activity, with differences in biocompatibility with human skin.