Journal
FERTILITY AND STERILITY
Volume 116, Issue 4, Pages 1098-1106Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2021.05.096
Keywords
Fertility preservation; ovarian tissue cryopreservation; ovarian tissue transplantation; return rate; follow-up
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Funding
- Research Pools of Rigshospitalet and Hyogo College of Medicine Hospital
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This study evaluated the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort, revealing that OTT rates depended on diagnosis, age at OTC, and follow-up time. Longer follow-up is needed, especially for younger girls.
Objective: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. Design: Retrospective cohort study. Setting: University hospitals and fertility clinics. Patient(s): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, ()TT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554). Intervention(s): OTC and OTT. Main Outcome Measure(s): OTT, death, donation of tissue. Result(s): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged >= 30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT. Conclusion(s): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls. (C) 2021 by American Society for Reproductive Medicine.
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