Journal
FERTILITY AND STERILITY
Volume 105, Issue 1, Pages 6-12Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2015.11.041
Keywords
Ovarian tissue cryopreservation; pediatric cancer; fertility preservation
Categories
Funding
- Medical Research Council [G1100357, G1002118, G0901839] Funding Source: Medline
- MRC [G1100357, G1002118, G0901839] Funding Source: UKRI
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With the increasing numbers of survivors of cancer in young people, future fertility and ovarian function are important considerations that should be discussed before treatment commences. Some young people, by nature of the treatment they will receive, are at high risk of premature ovarian insufficiency and infertility. For them, ovarian tissue cryopreservation (OTC) is one approach to fertility preservation that remains both invasive and for young patients experimental. There are important ethical and consent issues that need to be explored and accepted before OTC can be considered established in children with cancer. In this review we have discussed a framework for patient selection which has been shown to be effective in identifying those patients at high risk of premature ovarian insufficiency and who can be offered OTC safely. (C) 2016 by American Society for Reproductive Medicine.
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