Journal
FEBS LETTERS
Volume 595, Issue 16, Pages 2099-2112Publisher
WILEY
DOI: 10.1002/1873-3468.14154
Keywords
adipose tissue fibrosis; insulin resistance; LPS; macrophages; periostin; progenitor cells
Funding
- National Nature Science Foundation of China [31800970]
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The study showed that POSTN expression is increased in adipose tissue after LPS or HFD treatment, while deficiency of POSTN can reduce adipose tissue fibrosis and improve insulin resistance.
Periostin (POSTN) is a type of matricellular protein, but its functions in adipose fibrosis remain unclear. Here, we found that POSTN expression is significantly increased in mouse adipose tissue after treatment with lipopolysaccharide (LPS) or a high-fat diet (HFD) and that adipose progenitor cells are the main source of POSTN. In our mouse model of fibrosis, POSTN deletion protected mice from adipose fibrosis, probably through reducing the accumulation of macrophages and promoting adipocyte differentiation of progenitor cells. Taken together, our study demonstrates that POSTN deficiency attenuates adipose tissue fibrosis and improves insulin resistance, providing new insights into the diagnosis and treatment of type II diabetes by targeting adipose tissue fibrosis.
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