Journal
FEBS JOURNAL
Volume 289, Issue 20, Pages 6119-6131Publisher
WILEY
DOI: 10.1111/febs.16128
Keywords
actin; leiomodin; sarcomeres; tropomodulin; tropomyosin
Categories
Funding
- National Institutes of Health [GM120137, HL123078]
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Leiomodin is an important emerging regulator of thin filaments, and structural and cellular studies have helped elucidate its function mechanisms, with many domains still remaining unstudied. Future investigations may provide evidence that leiomodin is a multifunctional protein.
Leiomodin is an important emerging regulator of thin filaments. As novel molecular, cellular, animal model, and human data accumulate, the mechanisms of its action become clearer. Structural studies played a significant part in understanding the functional significance of leiomodin's interacting partners and functional domains. In this review, we present the current state of knowledge on the structural and cellular properties of leiomodin which has led to two proposed mechanisms of its function. Although it is known that leiomodin is essential for life, numerous domains within leiomodin remain unstudied and as such, we outline future directions for investigations that we predict will provide evidence that leiomodin is a multifunctional protein.
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