Journal
FERTILITY AND STERILITY
Volume 105, Issue 4, Pages 861-866Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2016.02.030
Keywords
Receptivity; implantation; endometrium; embryo
Categories
Funding
- Equipo IVI
- Igenomix
- Merck Serono
- Ferring
- MSD
- Ovascience
- Illumina
- Teva
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Embryonic implantation requires synchrony between the endometrium and the embryo. When analyzed in isolation, competent embryos may be unsuccessful when placed on a nonreceptive endometrium or vice versa, contributing to the black box'' of implantation failure. It is when the two are assessed together that dyssynchrony becomes evident, due to premature progesterone stimulus on the endometrium, physiologic displacement of the window of implantation or late blastulation of the embryo, or all combined. From the embryonic component, detailed assessment of the timing of blastulation is essential. The molecular diagnosis of endometrial receptivity based on its transcriptomic signature could be superior to other techniques used in the past for defining the endometrial window of implantation. (C) 2016 by American Society for Reproductive Medicine.
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