Journal
FERTILITY AND STERILITY
Volume 106, Issue 4, Pages 930-940Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2016.08.016
Keywords
Placenta; endocrine disrupting chemicals; assisted reproductive technologies; epigenetics
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Funding
- NICHD NIH HHS [P50 HD068157] Funding Source: Medline
- NIEHS NIH HHS [R01 ES023284, P30 ES013508] Funding Source: Medline
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In mammals, the extraembryonic tissues, which include the placenta, are crucial for embryonic development and growth. Because the placenta is no longer needed for postnatal life, however, it has been relatively understudied as a tissue of interest in biomedical research. Recently, increased efforts have been placed on understanding the placenta and how it may play a key role in human health and disease. In this review, we discuss two very different types of environmental exposures: assisted reproductive technologies and in utero exposure to endocrine-disrupting chemicals. We summarize the current literature on their effects on placental development in both rodent and human, and comment on the potential use of placental biomarkers as predictors of offspring health outcomes. (C) 2016 by American Society for Reproductive Medicine.
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