Normal intraocular pressure in Egyptian children and meta-analysis

OBJECTIVE: To determine the normal intraocular pressure in a sample of Egyptian children 0-12 years of age, and compare it to that recorded in previous studies. METHODS: This is a prospective cross-sectional study, including 345 eyes. All children underwent complete history taking and ophthalmic examination. Any glaucomatous patients or glaucoma suspects were excluded. Intraocular pressure was measured using Haag Streit Perkins M2 handheld applanation tonometer under topical or general anaesthesia. Three readings were recorded for each eye and the average was calculated. Central corneal thickness was measured, using handheld pachymeter (Pachmate 2), whenever possible. RESULTS: The study included 345 eyes of 187 children (101 males and 86 females), aged 2 months to 12 years (mean: 5.69 +/- 3.42 years). The recorded IOP was 5-20 mm Hg (mean: 11.5 +/- 2.34 mm Hg). Central corneal thickness was 469-742 mu m (mean: 564.8 +/- 42.72 mu m). The mean recorded intraocular pressure showed positive correlation with increased age (p = 0.026) and increased central corneal thickness (p = 0.037), with a difference of 1 mm Hg for every 100-mu m change in central corneal thickness. The mean IOP was significantly lower than that recorded by most previous studies. A detailed comparative analysis is presented comparing our findings with other studies including grouped analysis, by country, ethnicity and tonometers used. CONCLUSIONS: The mean IOP in a group of normal Egyptian children was 11.5 +/- 2.34mm Hg, with positive correlation to age and central corneal thickness. This mean intraocular pressure was lower than that previously reported in any other population.

Automated summary

The mean intraocular pressure in a group of normal Egyptian children was 11.5 +/- 2.34mm Hg, with positive correlation to age and central corneal thickness. This mean intraocular pressure was lower than that previously reported in any other population.