4.2 Review

Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic

Journal

EXPERT REVIEW OF PROTEOMICS
Volume 18, Issue 8, Pages 707-717

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14789450.2021.1976151

Keywords

Matrix metalloproteinase 8; Covid-19; oral fluids; diagnostics; mouth rinse; biomarkers; peri-implantitis; periodontitis

Funding

  1. Helsinki and Uusimaa Hospital District (HUS), Finland [TYH2016251, TYH2017251, TYH2018229, TYH2019319, Y1014SL017, Y1014SL018, Y1014SULE1]
  2. Suomen Hammaslaakariseura Apollonia (Finnish Dental Association Apollonia), Finland
  3. Karolinska Institutet, Sweden

Ask authors/readers for more resources

aMMP-8 is a potential biomarker for periodontal and peri-implant diseases, with POCT assays such as mouthrinse aMMP-8 being noninvasive and real-time for detection, treatment, and prevention. The clinical interdisciplinary utilization of aMMP-8 POCT requires further studies in oral, medical, and interdisciplinary fields.
Introduction Active matrix metalloproteinase (aMMP)-8 utilized in point-of-care testing (POCT) is regarded as a potential biomarker for periodontal and peri-implant diseases. Various host and microbial factors eventually influence the expression, degranulation, levels and activation of aMMP-8. The type of oral fluids (saliva, mouthrinse, gingival crevicular, and peri-implant sulcular fluids [GCF/PISF], respectively) affect the analysis. Areas covered With this background, we aimed to review here the recent studies on practical, inexpensive, noninvasive and quantitative mouthrinse and GCF/PISF chair-side POCT lateral flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyzer) and how they help to detect, predict, monitor the course, treatment and prevention of periodontitis and peri-implantitis. The correlations of aMMP-8 POCT to other independent and catalytic activity assays of MMP-8 are also addressed. Expert opinion The mouthrinse aMMP-8 POCT can also detect prediabetes/diabetes and tissue destructive oral side-effects due to the head and neck cancers' radiotherapy. Chlorhexidine and doxycycline can inhibit collagenolytic human neutrophil and GCF aMMP-8. Furthermore, by a set of case-series we demonstrate the potential of mouthrinse aMMP-8 POCT to real-time/online detect periodontitis as a potential risk disease for coronavirus disease 2019 (COVID-19). The clinical interdisciplinary utilization of aMMP-8 POCT requires additional oral, medical, and interdisciplinary studies.

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