4.3 Review

How effective are JAK-inhibitors? Perspectives from clinical trials and real-world studies

Journal

EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 18, Issue 3, Pages 207-220

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/1744666X.2021.1982383

Keywords

Comparative effectiveness; jak-inhibitors; janus kinase; rheumatoid arthritis; rheumatology; trials

Categories

Ask authors/readers for more resources

Trials of JAK-inhibitors have demonstrated efficacy in treating rheumatoid arthritis, but real-world studies evaluating their effectiveness are currently limited, especially for certain molecules. More high-quality studies are needed to assess the real-world effectiveness of JAK-inhibitors comprehensively.
Introduction JAK-inhibitors have emerged as a new treatment option for rheumatoid arthritis, with five molecules currently available in different parts of the world: tofacitinib, baricitinib, upadacitinib, peficitinib, and filgotinib. These molecules have been the subject of numerous trials looking at their efficacy (how well they perform in controlled conditions) but also some observational studies from the general population to assess their effectiveness (how well treatment perform under real conditions). With each their own weaknesses and strengths, they give different but complementary information. Areas covered We will review what we can learn from trials and real-world studies on how effective JAK-inhibitors are in the treatment of rheumatoid arthritis. Expert opinion Trials of JAK-inhibitors have shown that JAK-inhibitors are efficacious for the treatment of rheumatoid arthritis. However, their main outcomes are not clinically meaningful as their aim is mainly the regulatory authorization of the product. Real-world studies are important as they evaluate the real-life effectiveness of the compounds, however, they are scarce at the moment, mainly evaluating tofacitinib and of variable quality. Future high-quality studies are needed to assess the real-world effectiveness of JAK-inhibitors in a more complete manner.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available