SULT genetic polymorphisms: physiological, pharmacological and clinical implications

Introduction Cytosolic sulfotransferases (SULTs)-mediated sulfation is critically involved in the metabolism of key endogenous compounds, such as catecholamines and thyroid/steroid hormones, as well as a variety of drugs and other xenobiotics. Studies performed in the past three decades have yielded a good understanding about the enzymology of the SULTs and their structural biology, phylogenetic relationships, tissue/organ-specific/developmental expression, as well as the regulation of the SULT gene expression. An emerging area is related to the functional impact of the SULT genetic polymorphisms. Areas covered The current review aims to summarize our current knowledge about the above-mentioned aspects of the SULT research. An emphasis is on the information concerning the effects of the polymorphisms of the SULT genes on the functional activity of the SULT allozymes and the associated physiological, pharmacological, and clinical implications. Expert opinion Elucidation of how SULT SNPs may influence the drug-sulfating activity of SULT allozymes will help understand the differential drug metabolism and eventually aid in formulating personalized drug regimens. Moreover, the information concerning the differential sulfating activities of SULT allozymes toward endogenous compounds may allow for the development of strategies for mitigating anomalies in the metabolism of these endogenous compounds in individuals with certain SULT genotypes.

Automated summary

This review provides a comprehensive overview of various aspects of SULT research, with a focus on the impact of genetic polymorphisms on SULT allozyme activity and its implications on drug metabolism and physiological processes. Understanding how SULT SNPs affect drug-sulfating activity can help personalize drug regimens, while knowledge of differential sulfating activities of SULT allozymes towards endogenous compounds may lead to strategies for addressing metabolic anomalies in individuals with specific SULT genotypes.