Journal
FERTILITY AND STERILITY
Volume 106, Issue 5, Pages 1252-1257Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2016.06.039
Keywords
17-OHP; androgen; ACTH; polycystic ovary syndrome
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Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health (NIH) as part of the Specialized Cooperative Centers Program in Reproduction and Infertility Research, NIH [U54 HD12303-28, T32 HD007203]
- NIH [MO1 RR00827]
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Objective: To compare androgen responses during ACTH infusion among women with polycystic ovary syndrome (PCOS) and healthy women. Design: Cross-sectional study. Setting: Academic medical center. Patient(s): Women with PCOS (n = 13) and healthy controls (n = 15). Intervention(s): Blood samples were obtained frequently during a 6-hour dose-response ACTH infusion. Main Outcome Measure(s): Comparison of basal and stimulated levels of 17 alpha-hydroxyprogesterone (17-OHP), androgens, and cortisol (F) during ACTH infusion with those after hCG injection within individual subjects. Result(s): In women with PCOS increased 17-OHP, androstenedione (A), and DHEA responses during ACTH infusion were comparable to those observed in healthy controls. The magnitude of responses was highly variable among women with PCOS. Within individual women with PCOS adrenal responses to ACTH and ovarian responses to hCG were significantly correlated. Cortisol responses to ACTH were similar in women with PCOS and healthy controls. Conclusion(s): Within individual women with PCOS, enhanced androgen responses to ACTH are accompanied by comparable androgen responsiveness to hCG. These findings suggest that dysregulated steroidogenesis leading to hyperandrogenemia in this disorder is likely present in both adrenal and ovarian tissues. Clinical Trial Registration Number: NCT00747617. (Fertil Steril (R) 2016;106:1252-7. (C) 2016 by American Society for Reproductive Medicine.)
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