4.5 Article

Hallmarks of lens aging and cataractogenesis

Related references

Note: Only part of the references are listed.
Article Oncology

Extracellular vesicles promote epithelial-to-mesenchymal transition of lens epithelial cells under oxidative stress

Ruixin Wang et al.

Summary: The study found that EVs and ROS regulate epithelial-mesenchymal transition and migration of lens epithelial cells in PCO, suggesting that EVs may be a potential target for treating PCO.

EXPERIMENTAL CELL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Protection of ζ-crystallin by α-crystallin under thermal stress

Ajamaluddin Malik et al.

Summary: Camel lens proteins show resistance to cataractogenesis in harsh conditions, with α-crystallin playing a key role in preventing aggregation of ζ-crystallin at high temperatures, exhibiting significant chaperone activity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Biochemistry & Molecular Biology

Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins

Ana Alvarez-Barrios et al.

Summary: The human eye is greatly affected by both internal and external oxidants, leading to oxidative stress and potential eye diseases. Metallothioneins (MTs) are a family of proteins with antioxidant properties and cell-mediated functions that play a crucial role in capturing and neutralizing free radicals in the eye.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Death sentence: The tale of a fallen endoplasmic reticulum

Eoghan P. McGrath et al.

Summary: ER stress and the UPR are connected to identified death mechanisms like apoptosis, necrosis, pyroptosis, ferroptosis, and autophagy. These new findings provide actionable mechanisms for investigation and control in physiology and pathology.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Cell Biology

Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics

Jyoti Tanwar et al.

Summary: Mitochondria play a crucial role in regulating cellular energetics and survival functions through mitochondrial Ca2+ dynamics. This review focuses on the key molecular machinery involved in maintaining mitochondrial Ca2+ concentration, highlighting the importance of Ca2+ handling proteins in various physiological functions and human pathophysiology. Key outstanding questions in the field include further elucidating the specific mechanisms of mitochondrial Ca2+ regulation and related signaling pathways.

MITOCHONDRION (2021)

Article Biotechnology & Applied Microbiology

Protective Effect and Mechanism of Bone Morphogenetic Protein-4 on Apoptosis of Human Lens Epithelium Cells under Oxidative Stress

Bei Du et al.

Summary: Bone morphogenetic proteins (BMPs) are crucial in ocular tissues for lens development and cataract formation. BMP-4 has been shown to inhibit apoptosis of lens epithelial cells under oxidative stress by reducing caspase-3 activity and ROS levels, as well as regulating ATF-6 and KLF-6 expression.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Aging lens epithelium is susceptible to ferroptosis

Zongbo Wei et al.

Summary: This study reveals that lens epithelial cells are highly susceptible to ferroptosis, and aged and cataractous human lenses may possess more pro-ferroptotic criteria than any other organ in the human body.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Biochemistry & Molecular Biology

On the mechanism of calcium-dependent activation of NADPH oxidase 5 (NOX5)

Elisa Millana Fananas et al.

FEBS JOURNAL (2020)

Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease

Fatima Tuj Johra et al.

ANTIOXIDANTS (2020)

Article Medicine, Research & Experimental

Metformin Prevents H2O2-Induced Senescence in Human Lens Epithelial B3 Cells

Chunmei Zhang et al.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2020)

Review Ophthalmology

The potential role of nutrition on lens pathology: a systematic review and meta-analysis

Olympia Sideri et al.

SURVEY OF OPHTHALMOLOGY (2019)

Article Biochemistry & Molecular Biology

TRIM69 inhibits cataractogenesis by negatively regulating p53

Xianfang Rong et al.

REDOX BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics

Alice Rossi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Effect of Exogenous Zinc on MsrB1 Expression and Protein Oxidation in Human Lens Epithelial Cells

Yi Jia et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2019)

Review Biochemistry & Molecular Biology

Zeaxanthin: Metabolism, Properties, and Antioxidant Protection of Eyes, Heart, Liver, and Skin

Ana Gabriela Murillo et al.

ANTIOXIDANTS (2019)

Article Medicine, General & Internal

Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes

Ilona Kaczmarczyk-Sedlak et al.

ARCHIVES OF MEDICAL SCIENCE (2019)

Article Biochemistry & Molecular Biology

Histidine protects human lens epithelial cells against H2O2-induced oxidative stress injury through the NF-kB pathway

Jie Bai et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Biology

Xanthine oxidase activity in patients with age-related cataract associated with hypertension

B. Kisic et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2018)

Article Ophthalmology

Functional characterisation of glutathione export from the rat lens

Ankita Umapathy et al.

EXPERIMENTAL EYE RESEARCH (2018)

Review Biochemistry & Molecular Biology

Adaptive homeostasis and the free radical theory of ageing

Laura C. D. Pomatto et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Biochemical Research Methods

Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis

Fan Yang et al.

JOURNAL OF PROTEOME RESEARCH (2018)

Review Biochemistry & Molecular Biology

Functional role of peroxiredoxin 6 in the eye

Stephen Wahlig et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Biochemistry & Molecular Biology

Dynamic disulfide exchange in a crystallin protein in the human eye lens promotes cataract-associated aggregation

Eugene Serebryany et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Mercury-induced aggregation of human lens γ-crystallins reveals a potential role in cataract disease

J. A. Dominguez-Calva et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Roles of TGF β and FGF Signals in the Lens: Tropomyosin Regulation for Posterior Capsule Opacity

Eri Kubo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Editorial Material Biochemistry & Molecular Biology

γ-Crystallin redox-detox in the lens

Roy A. Quinlan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Ophthalmology

Nuclear and Mitochondrial DNA of Age-Related Cataract Patients Are Susceptible to Oxidative Damage

Ozlem Erol Tinaztepe et al.

CURRENT EYE RESEARCH (2017)

Review Nutrition & Dietetics

The antioxidants in the process of ocular pathology

Ana Fernandez-Araque et al.

NUTRICION HOSPITALARIA (2017)

Article Biochemistry & Molecular Biology

Parkin elimination of mitochondria is important for maintenance of lens epithelial cell ROS levels and survival upon oxidative stress exposure

Lisa Brennan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Biochemistry & Molecular Biology

Mitochondrial oxygen metabolism in primary human lens epithelial cells: Association with age, diabetes and glaucoma

M. Kubota et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Ophthalmology

The role of Prdx6 in the protection of cells of the crystalline lens from oxidative stress induced by UV exposure

Shinsuke Shibata et al.

JAPANESE JOURNAL OF OPHTHALMOLOGY (2016)

Review Chemistry, Analytical

Microarray analysis of metallothioneins in human diseases-A review

Sona Krizkova et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2016)

Review Pharmacology & Pharmacy

Cytoprotective mechanism of action of curcumin against cataract

Thiagarajan Raman et al.

PHARMACOLOGICAL REPORTS (2016)

Article Ophthalmology

The physiological optics of the lens

Paul J. Donaldson et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2016)

Article Ophthalmology

Nox4 Plays a Role in TGF-β-Dependent Lens Epithelial to Mesenchymal Transition

Shannon J. Das et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016)

Article Biochemistry & Molecular Biology

Antioxidant content and cytological examination of aqueous fluid from patients with age-related cataracts at different stages

X. Wang et al.

GENETICS AND MOLECULAR RESEARCH (2015)

Article Biochemistry & Molecular Biology

Thioredoxin Reductase Activity may be More Important than GSH Level in Protecting Human Lens Epithelial Cells against UVA Light

Vanita A. Padgaonkar et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2015)

Review Public, Environmental & Occupational Health

Vitamin E and risk of age-related cataract: a meta-analysis

Yufei Zhang et al.

PUBLIC HEALTH NUTRITION (2015)

Review Ophthalmology

The Photobiology of Lutein and Zeaxanthin in the Eye

Joan E. Roberts et al.

JOURNAL OF OPHTHALMOLOGY (2015)

Article Medicine, General & Internal

Cataract

Dennis Lam et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Ophthalmology

Loss of Thiol Repair Systems in Human Cataractous Lenses

Min Wei et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Article Oncology

Activation of the unfolded protein response in aged human lenses

He-Zhen Tang et al.

MOLECULAR MEDICINE REPORTS (2015)

Article Ophthalmology

Vitamin D deficiency and posterior subcapsular cataract

Craig J. Brown et al.

CLINICAL OPHTHALMOLOGY (2015)

Review Biochemistry & Molecular Biology

Methionine oxidation and reduction in proteins

Geumsoo Kim et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)

Article Biochemistry & Molecular Biology

Selenite cataracts: Activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection

Periyasamy Palsamy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Biochemistry & Molecular Biology

Alpha-crystallin-mediated protection of lens cells against heat and oxidative stress-induced cell death

Karen L. Christopher et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Article Biochemistry & Molecular Biology

The Protective Effect of Vanadium Against Diabetic Cataracts in Diabetic Rat Model

Lei Sun et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2014)

Review Pharmacology & Pharmacy

Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition

Mariko Nakano et al.

DRUG METABOLISM REVIEWS (2014)

Review Biochemistry & Molecular Biology

Roles and regulation of lens epithelial cell connexins

Viviana M. Berthoud et al.

FEBS LETTERS (2014)

Review Biochemistry & Molecular Biology

Revisiting an age-old question regarding oxidative stress

Yael H. Edrey et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Review Ophthalmology

Etiopathogenesis of cataract: An appraisal

Varun B. Gupta et al.

INDIAN JOURNAL OF OPHTHALMOLOGY (2014)

Article Biochemistry & Molecular Biology

Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset of Age-dependent Cataracts in Mice

Hongli Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Connexin 46 (Cx46) Gap Junctions Provide a Pathway for the Delivery of Glutathione to the Lens Nucleus

Nefeli Slavi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Ophthalmology

Unfolded protein response activation in cataracts

Beatriz E. Torres-Bernal et al.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2014)

Article Ophthalmology

Smoking Cessation and the Risk of Cataract A Prospective Cohort Study of Cataract Extraction Among Men

Birgitta Ejdervik Lindblad et al.

JAMA OPHTHALMOLOGY (2014)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Cell Biology

Genetic polymorphisms of HSP70 in age-related cataract

Yi Zhang et al.

CELL STRESS & CHAPERONES (2013)

Article Geriatrics & Gerontology

Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders

Motoko Kawashima et al.

EXPERIMENTAL GERONTOLOGY (2013)

Article Biochemistry & Molecular Biology

The role of melatonin as an antioxidant in human lens epithelial cells

J. Bai et al.

FREE RADICAL RESEARCH (2013)

Article Endocrinology & Metabolism

Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients

Dijana J. Miric et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2013)

Review Cell Biology

OPINION Protein homeostasis: live long, won't prosper

Brandon H. Toyama et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Cell Biology

Serum Antioxidative Enzymes Levels and Oxidative Stress Products in Age-Related Cataract Patients

Dong Chang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Review Biotechnology & Applied Microbiology

Antioxidant Delivery Pathways in the Anterior Eye

Ankita Umapathy et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Ophthalmology

Exploration of Molecular Factors Impairing Superoxide Dismutase Isoforms Activity in Human Senile Cataractous Lenses

Sankaranarayanan Rajkumar et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

Article Ophthalmology

The Effects of Age on Lens Transport

Junyuan Gao et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

Article Ophthalmology

Global estimates of visual impairment: 2010

Donatella Pascolini et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2012)

Article Ophthalmology

Enhanced age-related cataract in copper-zinc superoxide dismutase null mice

Eva M. Olofsson et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2012)

Review Ophthalmology

Magnesium deficiency: Does it have a role to play in cataractogenesis?

Renu Agarwal et al.

EXPERIMENTAL EYE RESEARCH (2012)

Article Ophthalmology

Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?

Roger J. W. Truscott et al.

EXPERIMENTAL EYE RESEARCH (2012)

Review Biochemistry & Molecular Biology

Protein misfolding and aggregation in cataract disease and prospects for prevention

Kate L. Moreau et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Article Cell Biology

Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis

Nigar Fatma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Article Physiology

TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells

Charalambos Michaeloudes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2011)

Article Biochemistry & Molecular Biology

Truncation, cross-linking and interaction of crystallins and intermediate filament proteins in the aging human lens

Shih-Ping Su et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)

Article Biochemistry & Molecular Biology

In vivo inhibition of 1-buthionine-(S,R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide

Joshua W. Carey et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Biochemistry & Molecular Biology

Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells

HongLi Wu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Biology

The ageing lens and cataract: a model of normal and pathological ageing

R. Michael et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)

Article Biochemistry & Molecular Biology

Curcumin prevents free radical-mediated cataractogenesis through modulations in lens calcium

Ramar Manikandan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Ophthalmology

Targeting CYP450 modulation to decrease the risk of induced cataract in the experimental model

D. V. Patel et al.

INDIAN JOURNAL OF OPHTHALMOLOGY (2010)

Article Zoology

A Network Perspective on Metabolism and Aging

Quinlyn A. Soltow et al.

INTEGRATIVE AND COMPARATIVE BIOLOGY (2010)

Review Biochemistry & Molecular Biology

The lens epithelium in ocular health and disease

G. Martinez et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Review Medicine, Research & Experimental

Non-thermal Cellular Effects of Low-power Microwave Radiation on the Lens and Lens Epithelial Cells

Y. Yu et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2010)

Article Ophthalmology

Effect of Age on the Thioltransferase (Glutaredoxin) and Thioredoxin Systems in the Human Lens

Kui-Yi Xing et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)

Article Ophthalmology

Oxygen Distribution in the Human Eye: Relevance to the Etiology of Open-Angle Glaucoma after Vitrectomy

Carla J. Siegfried et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)

Article Ophthalmology

Age-Dependent Deamidation of Lifelong Proteins in the Human Lens

Peter G. Hains et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)

Review Biochemistry & Molecular Biology

Oxidative Stress, Lens Gap Junctions, and Cataracts

Viviana M. Berthoud et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Article Ophthalmology

Phosphorylation and truncation sites of bovine lens connexin 46 and connexin 50

Zhen Wang et al.

EXPERIMENTAL EYE RESEARCH (2009)

Review Ophthalmology

The mechanisms of calcium homeostasis and signalling in the lens

Jeremy D. Rhodes et al.

EXPERIMENTAL EYE RESEARCH (2009)

Review Ophthalmology

Lens ion transport: From basic concepts to regulation of Na,K-ATPase activity

Nicholas A. Delamere et al.

EXPERIMENTAL EYE RESEARCH (2009)

Review Biochemistry & Molecular Biology

Glutathione: Overview of its protective roles, measurement, and biosynthesis

Henry Jay Forman et al.

MOLECULAR ASPECTS OF MEDICINE (2009)

Article Multidisciplinary Sciences

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

Viviana I. Perez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Ophthalmology

The Regulation of NADPH Oxidase and Its Association with Cell Proliferation in Human Lens Epithelial Cells

Yin Wang et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

Article Cell Biology

TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity

Eri Kubo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Article Veterinary Sciences

Effect of grape polyphenols on oxidative stress in canine lens epithelial cells

Curtis A. Barden et al.

AMERICAN JOURNAL OF VETERINARY RESEARCH (2008)

Article Endocrinology & Metabolism

High dosage of ascorbic acid and alpha-tocopherol is not useful for diminishing oxidative stress and DNA damage in healthy elderly adults

Raquel Retana-Ugalde et al.

ANNALS OF NUTRITION AND METABOLISM (2008)

Article Endocrinology & Metabolism

Association of serum alpha-tocopherol, retinol and ascorbic acid with the risk of cataract development

I. Nourmohammadi et al.

ANNALS OF NUTRITION AND METABOLISM (2008)

Review Biochemistry & Molecular Biology

Molecular mechanisms and clinical implications of reversible protein S-glutathionylation

John J. Mieyal et al.

ANTIOXIDANTS & REDOX SIGNALING (2008)

Article Ophthalmology

Activity of superoxide dismutase isoenzymes in lens epithelial cells derived from different types of age-related cataract

Sankaranarayanan Rajkumar et al.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2008)

Article Biology

Estrogen Protects against Radiation-Induced Cataractogenesis

Joseph R. Dynlacht et al.

RADIATION RESEARCH (2008)

Article Ophthalmology

Free and bound water in normal and cataractous human lenses

Karl R. Heys et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

Article Nutrition & Dietetics

Taurine prevents oxidative damage of high glucose-induced cataractogenesis in isolated rat lenses

Hee-Young Son et al.

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2007)

Review Pharmacology & Pharmacy

Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress

Molly M. Gallogly et al.

CURRENT OPINION IN PHARMACOLOGY (2007)

Editorial Material Biochemistry & Molecular Biology

Cell death modalities: classification and pathophysiological implications

L. Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Biochemistry & Molecular Biology

Low molecular weight protein tyrosine phosphatase (LMW-PTP) and its possible physiological functions of redox signaling in the eye lens

Kuiyi Xing et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2007)

Article Biochemistry & Molecular Biology

Reactive oxygen species mediates the apoptosis induced by transforming growth factor β2 in human lens epithelial cells

Ke Yao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Pharmacology & Pharmacy

Effect of magnesium deficiency on intracellular ATP levels in human lens epithelial cells

Noriaki Nagai et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)

Review Biochemistry & Molecular Biology

The lens circulation

Richard T. Mathias et al.

JOURNAL OF MEMBRANE BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Lens cells: More than meets the eye

Frederique M. D. Tholozan et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)

Article Multidisciplinary Sciences

Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model

Xingjun Fan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Oxidation-induced changes in human lens epithelial cells - 1. Phospholipids

Li Huang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Article Ophthalmology

Thioredoxin induced antioxidant gene expressions in human lens epithelial cells

Svitlana Yegorova et al.

EXPERIMENTAL EYE RESEARCH (2006)

Article Ophthalmology

Role of the unfolded protein response (UPR) in cataract formation

Kengo Ikesugi et al.

EXPERIMENTAL EYE RESEARCH (2006)

Article Ophthalmology

Levels of zinc, iron, and copper in patients with pseudoexfoliative cataract

T. Cumurcu et al.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2006)

Article Ophthalmology

Oxygen distribution in the rabbit eye and oxygen consumption by the lens

YB Shui et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2006)

Review Veterinary Sciences

Oxidation, antioxidants and cataract formation: a literature review

David L. Williams

VETERINARY OPHTHALMOLOGY (2006)

Article Endocrinology & Metabolism

Assessment of aqueous humor zinc status in human age-related cataract

I Nourmohammadi et al.

ANNALS OF NUTRITION AND METABOLISM (2006)

Article Ophthalmology

Accumulation of DNA, nuclear and mitochondrial debris, and ROS at sites of age-related cortical cataract in mice

W Pendergrass et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)

Review Biochemistry & Molecular Biology

Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

SG Rhee et al.

FREE RADICAL BIOLOGY AND MEDICINE (2005)

Article Ophthalmology

Growth factor receptor signalling in human lens cells: role of the calcium store

LX Wang et al.

EXPERIMENTAL EYE RESEARCH (2005)

Review Ophthalmology

Age-related nuclear cataract - oxidation is the key

RJW Truscott

EXPERIMENTAL EYE RESEARCH (2005)

Article Ophthalmology

Lens epithelial apoptosis and cell proliferation in human age-related cortical cataract

A Charakidas et al.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2005)

Review Biochemistry & Molecular Biology

Mitochondria, oxidants, and aging

RS Balaban et al.

Article Physiology

Connections between connexins, calcium, and cataracts in the lens

JY Gao et al.

JOURNAL OF GENERAL PHYSIOLOGY (2004)

Review Multidisciplinary Sciences

The pathophysiology of mitochondrial cell death

DR Green et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Age-dependent protein modifications and declining proteasome activity in the human lens

G Viteri et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)

Article Multidisciplinary Sciences

Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress

M Kantorow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Biochemistry & Molecular Biology

Ageing and vision: structure, stability and function of lens crystallins

H Bloemendal et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes

B Herrera et al.

FREE RADICAL BIOLOGY AND MEDICINE (2004)

Article Medicine, Research & Experimental

Apoptotic and necrotic mechanisms of stress-induced human lens epithelial cell death

AC Long et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2004)

Review Cell Biology

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

PS Brookes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)

Article Biochemistry & Molecular Biology

Possible physiological function of thioltransferase in cells

KY Xing et al.

FASEB JOURNAL (2003)

Review Ophthalmology

Redox regulation in the lens

MF Lou

PROGRESS IN RETINAL AND EYE RESEARCH (2003)

Article Ophthalmology

Human lens thioredoxin: Molecular cloning and functional characterization

S Yegorova et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2003)

Article Ophthalmology

Increased levels of advanced glycation end products in human cataractous lenses

S Franke et al.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2003)

Article Biochemistry & Molecular Biology

Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2

F Shang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2003)

Article Medical Laboratory Technology

Lens superoxide dismutase and catalase activities in diabetic cataract

B Özmen et al.

CLINICAL BIOCHEMISTRY (2002)

Article Multidisciplinary Sciences

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

JE Contreras et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

H2O2-mediated oxidative stress activates NF-κB in lens epithelial cells

EJ Dudek et al.

FREE RADICAL BIOLOGY AND MEDICINE (2001)

Article Biochemistry & Molecular Biology

Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2

VN Gladyshev et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms

M Lundberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Neurosciences

Regulation of cell function by methionine oxidation and reduction

T Hoshi et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)

Article Ophthalmology

Modulation of lens glycolytic pathway by thioltransferase

FY Qiao et al.

EXPERIMENTAL EYE RESEARCH (2000)

Article Ophthalmology

Glutathione: A vital lens antioxidant

FJ Giblin

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2000)

Article Cell Biology

Growth factor receptor gene and protein expressions in the human lens

DK Bhuyan et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2000)

Article Biochemistry & Molecular Biology

Lens epithelium-derived growth factor: Effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts

DP Singh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)