Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 246, Issue 24, Pages 2553-2558Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/15353702211038894
Keywords
Cell; autophagy; cell autophagy; atherosclerosis; atherosclerotic plaque; stability
Categories
Funding
- Hunan Provincial Natural Science Foundation [2019JJ40248]
- National Natural Sciences Foundation of China [82060091, 81770490]
Ask authors/readers for more resources
Cardiovascular and cerebrovascular diseases caused by atherosclerosis are major health threats, with autophagy playing a key role in plaque development. Further research is needed to understand the mechanisms involved.
Cardiovascular and cerebrovascular diseases, such as coronary heart disease and stroke, caused by atherosclerosis have become the number one killer, seriously endangering human health in developing and developed countries. Atherosclerosis mainly occurs in large and medium-sized arteries and involves intimal thickening, accumulation of foam cells, and formation of atheromatous plaques. Autophagy is a cellular catabolic process that has evolved to defend cells from the turnover of intracellular molecules. Autophagy is thought to play an important role in the development of plaques. This review focuses on studies on autophagy in cells involved in the formation of atherosclerotic plaques, such as monocytes, macrophages, endothelial cells, dendritic cells, and vascular smooth muscle cells, indicating that autophagy plays an important role in plaque development. We mainly discuss the roles of autophagy in these cells in maintaining the stability of atherosclerotic plaques, providing a reference for the next steps to unravel the mechanisms of atherogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available