Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 246, Issue 24, Pages 2589-2594Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/15353702211036055
Keywords
LIPCAR; biomarker; acute myocardial infarction; heart failure
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Funding
- Key Special Construction Project of Pudong Health and Family Planning Commission of Shanghai [PWZzk2017-23]
- Science and Technology Development Foundation of Pudong New Area [PKJ2020-Y26]
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The study found that LIPCAR levels were elevated in HF patients post-AMI and had a high predictive value for the diagnosis of HF, suggesting that LIPCAR may serve as a marker for early HF after AMI.
In heart failure (HF) patients with reduced ejection fraction, LIPCAR, a long noncoding RNA is elevated and is associated with left ventricular remodeling and poor prognosis. We studied the role of LIPCAR in patients with HF post-acute myocardial infarction (AMI) to find biomarkers for early detection of HF. We conducted a study of 127 patients with AMI, of which 59 were patients with HF post-AMI. LIPCAR levels were higher in HF patients post-AMI than patients without HF, and LIPCAR had a high predictive value for diagnosis of HF, which was estimated by receiver operating characteristic curves (AUC: 0.985). The results indicate that LIPCAR may be a marker of early HF after AMI.
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