The Importance of Muscle Capillarization for Optimizing Satellite Cell Plasticity

Satellite cells are essential for skeletal muscle regeneration, repair, and adaptation. The activity of satellite cells is influenced by their interactions with muscle-resident endothelial cells. We postulate that the microvascular network between muscle fibers plays a critical role in satellite cell function. Exercise-induced angiogenesis can mitigate the decline in satellite cell function with age.

Automated summary

Satellite cells are crucial for skeletal muscle regeneration, repair, and adaptation, their activities are influenced by interactions with muscle-resident endothelial cells. The microvascular network between muscle fibers plays a critical role in satellite cell function, and exercise-induced angiogenesis can help mitigate the decline in satellite cell function with age.