Markedly decreasing azithromycin susceptibility of Neisseria gonorrhoeae, Germany, 2014 to 2021

Article Infectious Diseases

Emergence and dissemination of three mild outbreaks of Neisseria gonorrhoeae with high-level resistance to azithromycin in Barcelona, 2016-18

P. Salmeron et al.

Summary: This study characterized the first 16 Neisseria gonorrhoeae isolates with high-level azithromycin resistance (HL-AziR) in Barcelona between 2016 and 2018. WGS was used to identify antimicrobial resistance mechanisms and clonal relatedness, revealing three transmission clusters associated with sexual behavior. The findings highlight the continuous development and spread of antimicrobial resistance in N. gonorrhoeae, supporting enhanced outbreak investigation and public health measures for prevention and control of multi-drug resistant strains.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

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Article Immunology

Sustained Transmission of Neisseria gonorrhoeae with High-Level Resistance to Azithromycin, in Indianapolis, Indiana, 2017-2018

Justin L. Holderman et al.

Summary: A cluster of 14 Neisseria gonorrhoeae isolates with high-level azithromycin resistance was identified in Indiana, primarily among white men who have sex with men. Although few patients named each other as partners, genomic sequencing revealed isolates as closely related.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Infectious Diseases

Neisseria gonorrhoeae antimicrobial resistance in Spain: a prospective multicentre study

Paula Salmeron et al.

Summary: The study in Spain reveals high susceptibility of Neisseria gonorrhoeae to extended-spectrum cephalosporins, while exhibiting high resistance to azithromycin and ciprofloxacin. The MIC50 and MIC90 values for gentamicin and fosfomycin are also provided, highlighting the importance of updating national treatment guidelines and establishing a national sentinel gonococcal antimicrobial susceptibility programme.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

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Article Immunology

The Mosaic mtr Locus as Major Genetic Determinant of Azithromycin Resistance of Neisseria gonorrhoeae-Germany, 2018

Sebastian Banhart et al.

Summary: The resistance of Neisseria gonorrhoeae to azithromycin within the German Gonococcal Resistance Network increased from 4.3% in 2016 to 9.2% in 2018. The rise in resistance was primarily clonal and linked to a specific mtr locus. The international spread of resistant lineages was identified as a major factor contributing to azithromycin resistance in Germany.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Immunology