Journal
EUROPEAN POLYMER JOURNAL
Volume 160, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2021.110776
Keywords
Sodium alginate; Chitosan; LbL; Mechanical resistance; Hybrid release model
Categories
Funding
- Polish Ministry of Science and Higher Education for the Faculty of Chemistry of Wroclaw University of Science and Technology
- Jerzy Haber Institute of Catalysis and Surface Chemistry PAS
Ask authors/readers for more resources
In this study, multilayered alginate/chitosan microparticles were fabricated to enhance the oral administration of large cranberry fruit extracts. The size and properties of the microparticles were influenced by the outermost layer composition. The microparticles showed good drug entrapment efficiency and release profiles.
We present a series of multilayered alginate/chitosan microparticles fabricated via combining ionic gelation with the layer-by-layer (LbL) approach to improve oral administration of large cranberry fruit extract (CFE). Sodium alginate of low (ALGlv) or medium (ALGmv) viscosity was used as a core polymer, and chitosan (CHIT) and ALGmv layers were alternately assembled to form up to seven layers' coating. Microparticles size ranged between 640 and 1120 mu m, and their morphology, moisture content, and structural integrity were affected mainly by the outermost layer's composition. Both the microgel core and shell composition of these microparticles influenced the mechanical properties determined by the parallel plates compression test. Microparticles exhibited good CFE entrapment efficiency (E.E. > 55%) and favorable release profiles in the simulated gastro-intestine environment, well described by the hybrid model of the release kinetics. Our results evidence that polysaccharide-inspired microparticles are good platforms for enhancing the oral bioavailability of poorly water-soluble therapeutic agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available