Morphologies of compressed active epithelial monolayers

Using a three-dimensional active vertex model, we numerically study the shapes of strained unsupported epithelial monolayers subject to active junctional noise due to stochastic binding and unbinding of myosin. We find that while uniaxial, biaxial, and isotropic in-plane compressive strains do lead to the formation of longitudinal, herringbone pattern, and labyrinthine folds, respectively, the villus morphology characteristic of, e.g., the small intestine appears only if junctional tension fluctuations are strong enough to fluidize the tissue. Moreover, the fluidized epithelium features villi even in the absence of compressive strain provided that the apico-basal differential surface tension is large enough. We analyze several details of the different epithelial forms including the role of strain rate and the modulation of tissue thickness across folds. Our results show that even unsupported, non-patterned epithelia can form nontrivial morphologies.

Automated summary

Using a three-dimensional active vertex model, this study numerically investigates the shapes of strained unsupported epithelial monolayers subject to active junctional noise. The research reveals that different types of compressive strains lead to different fold morphologies, and villus morphology appears only when junctional tension fluctuations are strong enough to fluidize the tissue. Additionally, fluidized epithelium can form villi even in the absence of compressive strain under large apico-basal differential surface tension.