Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 54, Issue -, Pages 90-99Publisher
ELSEVIER
DOI: 10.1016/j.euroneuro.2021.09.001
Keywords
Bipolar disorder; Vaccination; COVID-19; Infectious diseases; Systematic review
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Patients with bipolar disorder may have a higher risk of contracting COVID-19, leading to worsened clinical outcomes. However, research on vaccination in individuals with BD is limited and lacks substantial evidence.
Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
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