Neurite orientation dispersion and density imaging in evaluation of high-grade glioma-induced corticospinal tract injury

Purpose: To evaluate the application of neurite orientation dispersion and density imaging (NODDI) to brain glioma-induced corticospinal tract (CST) injury. Material and methods: Twenty-four patients with high-grade glioma (HGG) in or adjacent to the CST pathway and 12 matched healthy subjects underwent structural and diffusion MRI. The CSTs were reconstructed on the both sides. The CST features including morphological features (track number, average track length and track volume) and the diffusion parameter values including fractional anisotraphy (FA), mean diffusivity (MD), intracellular volume fraction (ICVF), isotropic or free water volume fraction (ISOVF) and orientation dispersion index (ODI) along the CST were calculated. The CST features were compared between the affected and healthy side for HGG patients and between the left and right side for healthy subjects. The relative CST features were compared across the healthy subjects, patients with motor weakness and patients with normal muscle strength. Receiver operating characteristic (ROC) curve was applied to evaluate the performance of each relative CST characteristic for HGGinduced CST changes. Results: Compared with the CST features on the healthy side, the track number, track volume and FA along the CST changed significantly on the affected side for HGG patients (p < 0.05 for all), whereas MD and ICVF changed significantly on the affected side only for HGG patients with motor weakness (p = 0.012 for both). In patients with motor weakness, the relative MD was significantly higher (p < 0.001), whereas the relative FA and ICVF was significantly lower (p = 0.002 and <0.001) than those in patients with normal muscle strength. The relative ICVF had a similar area under curve (AUC) to that of MD (AUC=0.953 and 0.969). Compared with the relative CST features in the healthy subjects, only the relative ICVF was significantly lower in HGG patients with normal muscle strength (p = 0.012). Conclusions: NODDI seems to be useful in reflecting the HGG infiltration to CST, and can evaluate the CST destruction with a performance similar to DTI by providing additional information about neurite density for HGG-induced CST injury.

Automated summary

The study evaluated the application of NODDI in assessing brain glioma-induced CST injury. Results showed significant changes in CST features on the affected side for HGG patients, with track number, track volume, and FA decreasing, while MD and ICVF changed only in patients with motor weakness. The relative ICVF exhibited high sensitivity in diagnosing HGG-induced CST changes.