4.5 Article

Imaging and treatment of brain tumors through molecular targeting: Recent clinical advances

Journal

EUROPEAN JOURNAL OF RADIOLOGY
Volume 142, Issue -, Pages -

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2021.109842

Keywords

Molecular imaging; Brain tumor; Glioma; PET; MRI; Theranostics

Funding

  1. NIHR Cambridge Biomedical Research Centre [BRC-1215-20014]
  2. Cancer Research UK (CRUK)

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Advancements in molecular imaging techniques have provided valuable insights into neuro-oncological imaging, offering potential solutions for key challenges in brain tumor patient management.
Molecular imaging techniques have rapidly progressed over recent decades providing unprecedented in vivo characterization of metabolic pathways and molecular biomarkers. Many of these new techniques have been successfully applied in the field of neuro-oncological imaging to probe tumor biology. Targeting specific signaling or metabolic pathways could help to address several unmet clinical needs that hamper the management of patients with brain tumors. This review aims to provide an overview of the recent advances in brain tumor imaging using molecular targeting with positron emission tomography and magnetic resonance imaging, as well as the role in patient management and possible therapeutic implications.

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