Review of eosinophilic oesophagitis in children and young people

Eosinophilic oesophagitis is a relapsing inflammatory disorder involving oesophagus identified over 30 years ago. Diagnosis is made by upper gastrointestinal endoscopy and oesophageal biopsies. There is huge variation in management practices across the globe. Therapeutic options include the use of proton pump inhibitors, topical steroids, and elimination diet. Biologics and immunomodulator drugs are being explored but not yet recommended in children. Long-term treatment may be required to control symptoms and to prevent complications such as fibrosis/stricture. Conclusion: Even though clinicians have better understanding of eosinophilic oesophagitis, further research is warranted in exploring the unmet needs of developing a highly sensitive non-invasive biomarker for its diagnosis and response to treatment along with a robust and easily deliverable therapeutic option.

Automated summary

Eosinophilic oesophagitis is a chronic inflammatory disorder involving the esophagus, diagnosed by upper gastrointestinal endoscopy and esophageal biopsies. There is significant variation in treatment practices, including medications and dietary changes. Long-term treatment may be necessary to control symptoms and prevent complications.